Last updated on April 17, 2025 by

Mounjaro Refrigeration and Storage

Mounjaro (tirzepatide) is an innovative treatment for type 2 diabetes and obesity, developed by Eli Lilly. Proper storage of Mounjaro is crucial to maintaining its effectiveness and ensuring it delivers the desired therapeutic benefits. This article will provide a comprehensive guide to storing Mounjaro, answering the most common questions about refrigeration, shelf life, and safe handling.

Why Does Mounjaro Need to Be Refrigerated?

Mounjaro is a biologic medication, and its protein-based structure is sensitive to temperature. Refrigeration is essential to preserve its stability and ensure it works effectively. Storing Mounjaro at the proper temperature (36°F/2°C to 46°F/8°C) prevents degradation of its active ingredients, which could otherwise result in reduced potency and effectiveness.

How to Store Mounjaro

  • Room Temperature Use: Mounjaro can be safely kept at room temperature (up to 86°F/30°C) for up to 21 days, but it should be returned to the fridge if not used within this time frame.
  • Refrigeration: Always store Mounjaro in the fridge, ideally between 36°F (2°C) and 46°F (8°C).
  • Original Packaging: Keep the medication in its original packaging to protect it from light and prevent accidental exposure to temperature extremes.
  • Avoid Freezing: Never freeze Mounjaro, as freezing can alter its composition.

What Happens If Mounjaro Is Not Refrigerated?

If Mounjaro is not stored at the proper temperature, the biologic components may degrade. This means the medication may lose its potency, reducing its effectiveness in treating type 2 diabetes or promoting weight loss. If Mounjaro is exposed to temperatures higher than 86°F (30°C) for more than a brief period or remains outside of refrigeration for extended durations, it should be discarded. Its therapeutic effects will be compromised, and it may no longer provide the desired health benefits.

How Long Can Mounjaro Be Out of the Fridge?

Mounjaro can be kept at room temperature for a maximum of 21 days, as long as the temperature does not exceed 86°F (30°C). Once the 21-day period has passed, the medication should be disposed of, even if it appears to be in good condition. During this period, it is essential to ensure that Mounjaro is kept away from direct sunlight, heat sources, and high temperatures. If any of these conditions are violated, the medication should be discarded immediately.

How to Store Mounjaro Safely at Room Temperature?

If you need to store Mounjaro outside of the refrigerator for any reason, follow these steps to ensure its stability:

  • Temperature Control: Ensure the storage location does not exceed 86°F (30°C). Avoid places like cars, windowsills, or areas near heaters or stoves.
  • Light Protection: Keep Mounjaro in its original packaging. The packaging is designed to protect it from light, which could degrade its active ingredients.
  • Avoid Direct Sunlight: Store the medication in a cool, dark location, such as a drawer or cabinet, to shield it from sunlight and heat.
  • Use a Cooling Case: If traveling, use a medical-grade cooler to ensure the medication stays within the safe temperature range. This is particularly important in warm climates or during summer months.

How Long Does Mounjaro Last in the Fridge?

When stored correctly in the refrigerator, Mounjaro can last until the expiration date printed on the packaging, which is usually around one year from the date of purchase. It is important to keep track of this expiration date and ensure that the cold chain has not been interrupted during storage. As long as Mounjaro has remained at the proper temperature, it can remain effective up to this date. Always check the label for the specific expiration date.

How Long Is Mounjaro Good For? Does Mounjaro Expire?

Mounjaro has two types of expiration dates:

  • Manufacturer Expiration: This is the date printed on the packaging by Eli Lilly. It typically indicates the time frame in which the medication remains stable when stored in a refrigerator (between 36°F and 46°F).
  • Room Temperature Expiration: Once Mounjaro has been removed from the fridge, it is only safe to use for up to 21 days, regardless of the manufacturer’s expiration date. After this time, the medication should be discarded, even if it still appears intact.

If you ever suspect that your Mounjaro has been exposed to higher temperatures for an extended period or has passed the 21-day window, do not use it. Always replace it with a new, properly stored vial or pen.

Can You Freeze Mounjaro?

No, Mounjaro should never be frozen. Freezing can alter the molecular structure of the medication, leading to a loss of efficacy. If Mounjaro is accidentally frozen, discard it immediately, even if it has thawed afterward. Always ensure that your refrigerator is set to the correct temperature and avoid placing Mounjaro near the freezer compartment.

What Happens If Your Mounjaro Injections Get Warm?

If Mounjaro is exposed to high temperatures (above 86°F or 30°C), the active ingredients can break down and lose their effectiveness. If you suspect that Mounjaro has been exposed to heat for a prolonged period, discard it and replace it with a new vial or pen that has been stored properly. Even brief heat exposure, such as leaving the medication in a hot car, can compromise its potency.

What Is the Shelf Life of Mounjaro?

The shelf life of Mounjaro, when refrigerated, is typically up to one year, as indicated on the packaging. However, once it has been removed from the fridge, the medication has a limited shelf life of 21 days at room temperature. After 21 days, the medication should no longer be used and must be discarded. Be sure to monitor both the manufacturer’s expiration date and the 21-day room temperature limit.

FAQ

Can I put Mounjaro back in the fridge after it’s been at room temperature?

Once Mounjaro has been stored at room temperature for up to 21 days, it should not be returned to the fridge. The medication may have already begun to degrade, and refrigerating it again will not restore its effectiveness.

Can I travel with Mounjaro?

Yes, you can travel with Mounjaro, but it is essential to keep the medication within its recommended temperature range (36°F to 46°F or 2°C to 8°C). Use a medical cooler or insulated case to protect Mounjaro from temperature extremes during travel, especially in hot climates.

How can I tell if my Mounjaro has gone bad?

If Mounjaro appears cloudy, discolored, or contains visible particles, it may have degraded and should not be used. Always inspect the appearance of the medication before use and consult your pharmacist if you have any concerns.

Conclusion

Proper refrigeration and careful handling of Mounjaro are essential to ensure it remains safe and effective for managing type 2 diabetes and weight loss. By following these storage guidelines and keeping track of expiration dates, you can maximize the medication’s therapeutic benefits. If you have any doubts about the condition of your medication, consult your pharmacist for advice.